William Ronchetti

1. Data Product Engineer

   Sept 2024 — Present

   Novo Nordisk (via Kelly Services Global) · Remote

   • Spearhead development of the Omics Platform, an internal AWS system managing petabytes of diverse omics data for dozens of research teams — both cataloguing and analysis.
   • Built a highly scalable ingestion pipeline on Lambda, Glue, and Batch for validation and transfer of raw data and discovery metadata across several dozen vendors/CROs.
   • Designed a metadata model for tracking diverse omics datasets using Parquet and Amazon Athena.
   • Review code and mentor a small team on software, cloud-engineering, and security best practices to ensure GDPR compliance.
   • AWS Lambda
   • Glue
   • Batch
   • Parquet
   • Athena
   • Python

2. Senior Software Engineer

   Aug 2019 — Present

   Harvard Medical School — Dept. of Biomedical Informatics · Remote / Boston, MA

   Senior since 2022 (half-time since Jan 2025) — previously Software Engineer

   • Lead back-end development in Python for the CGAP, 4DN, and SMaHT data platforms, supporting petabytes of raw data and associated metadata.
   • Refactored complex, organically grown AWS infrastructure into reproducible infrastructure-as-code (CloudFormation), achieving FISMA-Moderate compliance and passing multiple independent security audits.
   • Migrated the web platform from Apache on Elastic Beanstalk to Nginx on ECS Fargate, cutting compute costs by 50% with configurable autoscaling.
   • Implemented observability with structured event logging via a Splunk HEC pipeline and container log shipping through FireLens / Fluent Bit.
   • Optimized Postgres and Elasticsearch query performance by resolving aggregation timeouts from large terms filters — 50% faster responses.
   • CloudFormation
   • ECS Fargate
   • Nginx
   • PostgreSQL
   • Elasticsearch
   • Splunk
   • FISMA

3. Associate in Research (part-time)

   Feb 2019 — Present

   Duke University — Dept. of Electrical & Computer Engineering · Durham, NC

   • Develop assignments for an advanced C++ course and improve introductory C programming assignments on Coursera; support students with C and Python coursework.

4. Teaching Assistant (part-time)

   Aug 2016 — Dec 2018

   Cornell University · Ithaca, NY

   • Taught Operating Systems (CS 4410/4411) and System Security (CS 5430/5431) with practicum sections; built and improved C autograders and graded exams.

Co-author on 5 peer-reviewed publications for data-platform and pipeline contributions, with 267 citations. Selected highlights:

• The Somatic Mosaicism across Human Tissues Network Nature · 2025
• An integrated view of the structure and function of the human 4D nucleome Nature · 2025
• Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations Nature Communications · 2025
• The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data Nature Communications · 2022